Glutamine PlusGlutamine Plus ™ is a pure L-Glutamine mixed with Magic Fiber CLR™ (A source of soluble fiber). As this product has virtually no taste and mixes readily with water, we recommend mixing with water only. Do not mix with highly acidic sodas. Glutamine Plus™140 grams powder--43 servings per bottleOne serving contains (1 rounded tsp): L-Glutamine 2000 mg Magic Fiber™CLR 1250 mg |
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There is no single recommended dose of glutamine. Generally 4 to
8 g /day are used in divided doses for people under increased
stress because of dieting, heavy exercise, flu, diarrhea, upper gastrointestinal
problems, such as stomach ulcers, or for intestinal
bowel problems. Glutamine should be taken with room temperature water, as heat
destroys glutamine. Glutamine can also be taken with food at room
temperature, but not mixed with highly acidic products like vinegar.
(Applesauce is okay.)
Note: Restrictions and Contraindications at the bottom of this information.
Glutamine Plus ™ UsagePost Surgery PatientsWhen individuals undergo an operation (such as removal of the gallbladder), There is an increased breakdown of skeletal muscle, a release of amino acids into the bloodstream, and a fall of glutamine levels in the skeletal muscles. When glutamine is used, the muscle breakdown rates are greatly diminished. Athletes and BodybuildersStrenuous exercise may cause loss of muscle mass due to metabolic reactions that create a surplus of acid (acidosis). This excessive acid, in turn, triggers a breakdown of muscle and the release of glutamine, allowing glutamine to donate an essential molecule to neutralize the positive charge of the acid in the kidneys. Supplemental glutamine can prevent acidosis and reduce muscle breakdown. Intestinal (Digestive System) RepairThe cells that line the gastrointestinal tract take lots of abuse from
food breakdown, the release of hydrochloric acid in the stomach
and the development of waste products and toxins. The lining of
the small intestine is known as the mucosa. The mucosa is composed
of fingerlike projections called villi, where the actual intestinal
cells, the enterocytes, are located. The enterocytes are some of
the most rapidly multiplying cells in the body. The primary nutrient
for these cells is glutamine. |
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There are occasions when people are unable to eat for extremely long periods of time because of an illness such as inflammatory bowel disease, chemotherapy, or radiation. Under these conditions, the ability of the intestine to maintain itself starts to wane. Because demand exceeds supply, the level of Glutamine in the blood begins to fail. Cell replication becomes much slower, muscle is significantly wasted, and the intestines severely atrophy. Recovery time is prolonged.
Chemotherapy works against cancerous growth by destroying rapidly growing cells. However, chemotherapy attracts and destroys not only cancer cells but also cells of the intestinal tract, which are the fastest growing cells in the body. This may contribute to the nausea, vomiting, and diarrhea suffered by people who are being treated for cancer. Radiation has a similar effect and is toxic to the gastrointestinal tract, especially at high doses. Animal studies have shown that Glutamine helps protect the intestinal lining during treatment. (4 to 8 grams per day in divided dose.)
Japanese scientists have discovered that Glutamine is an effective anti-ulcer agent for the stomach. In other studies, they discovered they could enhance the healing of peptic stomach ulcers by giving test subjects oral Glutamine. Glutamine has also been found to be important in diminishing the loss of electrolytes and water from the intestines during diarrhea. Glutamine could help enhance water and salt intake into the body and could help lessen diarrhea. Glutamine has also been found to be an important nutrient for the large bowel (the colon) and can provide fuel to maintain the normal function of the mucosal lining cells of the colon.
The liver is both a glutamine producer and a glutamine consumer. The liver rids itself of excess nitrogen in the form of ammonia in two ways: 1) It uses the nitrogen to form urea and, ultimately, excretes it as urine. 2) It also attaches the nitrogen to the amino acid glutamate to form glutamine. Glutamate is combined with cysteine and glycine to manufacture glutathione, the body’s number one antioxidant.
When there is an over abundance of calories (such as high carbohydrate diets), or when there is partial fasting and rapid liberation of fat from the body’s fat stores (as occurs with severely restricted weight loss diets), the liver becomes choked with fat. Such a liver is called a fatty liver. The liver has taken up too much fat and cannot get rid of it. It becomes enlarged and shows signs of dysfunction that show up when liver tests are performed. Scientists have discovered that the formation of a fatty liver can be prevented by the addition of glutamine to the diet.
People with an auto-immune disease, like rheumatoid arthritis, have a 50% greater production of cytokines in circulating cells of their blood than do people without an auto-immune disease. They often have chronic pain at the site of inflammation and increased muscle wasting from cytokine production or from the steroids used to treat their conditions. It has been shown that glutamine, by contributing to the production of glutathione, is able to stop the production of cytokines when they are being synthesized in amounts harmful to the body.
Glutamine can protect the stomach somewhat from gastritis caused by NSAIDS. Small quantities of glutamine may help individuals with depression (250 to 1000 mg). Glutamine may have some potential for curbing addiction to alcohol. (Studies done at 1000 mg per day). Glutamine is being used at the Brigham and Women’s Hospital in Boston to help heal mouth sores and oral mycositis (inflammation of the skin of the mouth), and ease the pain of cancer. The general recommendation is approximately 5,000 mg with water. Patients swish the solution around in the mouth for a few seconds and then swallow.
Some people should not take glutamine. It should probably not be used by patients with chronic renal failure (kidney disease). Patients with liver disease, especially severe liver disease, should not use glutamine without their doctor’s recommendation. Patients with severe cirrhosis of the liver, Reye’s Syndrome, or certain other metabolic disorders should not use Glutamine.
Glutamine has been used up to .75 g per kilogram of body weight. This is the equivalent of 68 g (68,000 mgs) for a 150 lb. person. No adverse effects have been noted. High levels like this should always be done under a doctor’s supervision.
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The information provided above is intended for educational purposes only.
It is not meant to either directly or indirectly give medical advice or prescribe treatment.
Unless specifically referenced, the information has not been scientifically validated or approved by any
government or regulatory agency. Please consult with your physician or other licensed health care
professional for medical diagnosis, prescription, and treatment. |
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